Marine Collagen and the Scientific Facts: 2022

There have been numerous clinical studies which review the use of marine collagen peptides (from fish).  The focus of these clinical studies has been the effect of collagen peptides supplementation on skin hydration, skin elasticity and the reduction in fine lines and wrinkles.  These studies have not reported any side effects. We present the most relevant studies and keep you updated on a regular basis.  We are just introducing a selection of studies and findings.

As we know, collagen synthesis changes as we age.  Younger skin has 80% Type I collagen and about 15% Type III collagen. NYME Collagen+ contains Type I and Type III collagen. As we age, collagen fibers become thicker and shorter and Type I collagen is greatly reduced. When combined with a reduction of hyaluronic acid, these factors contribute to the appearance of ageing skin,  reduction in skin elasticity and increased appearance of  wrinkles [1-2].

Most studies involve taking collagen supplements for 12-24 weeks . The average daily dose of collagen is 5-10g (5,000-10,000mg). No side effects have been reported. The studies show improvements in the following:

Skin softness: improved in 35% and 54% of participants receiving collagen peptides after 28 and 56 days of treatment, respectively [7].

Skin smoothness: improved in 27% and 46% in participants receiving a collagen peptide supplement, after 28 and 56 days of treatment, respectively [7].

Skin firmness: improved in 27% and 58% of participants taking a collagen supplement, after 28 and 56 days of treatment, respectively [7].

Wrinkle visibility: reduced in 38% of participants in the collagen peptide group after 56 days of treatment [7].

Collagen has also been used in wound healing and bone regeneration.

There are some interesting facts when it comes to collagen and the menopause. Type I and III skin collagen is thought to decrease by as much as 30% in the first five years after menopause [8,9].

If you have any specific questions, please email us: 


1. Naylor EC, Watson RE, Sherratt MJ. Molecular aspects of skin ageing. Maturitas. 2011;69(3):249–56.
2. Sara Sibilla, Martin Godfrey, Sarah Brewer, Anil Budh-Raja, Licia Genovese. An Overview of the Beneficial Effects of Hydrolyzed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies. The Open Nutraceuticals Journal. 2015;8:29–42
3. Reilly DM, Lozano J. Skin collagen through the life stages: importance for skin health and beauty. Plast Aesthet Res. 2021;8:2. doi: 10.20517/2347-9264.2020.153.
4. De Melo F, Nicolau P, Piovano L, et al. Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®) Clin Cosmet Investig Dermatol. 2017;10:431–440. doi: 10.2147/CCID.S145195.
5. Li P, Wu G. Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids. 2018;50(1):29–38. doi: 10.1007/s00726-017-2490-6.
6. Felician FF, Xia C, Qi W, Xu H. Collagen from marine biological sources and medical applications. Chem Biodivers. 2018;15(5):e1700557. doi: 10.1002/cbdv.201700557.
7. Evaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin Moisturization, Smoothness, and Wrinkles. Ferdinando Marco Bianchi, MD, Claudio Angelinetta, MS, Gaetana Rizzi, MS, Antonella Praticò, MS, and Roberta Villa, MS. 2022 Mar; 15(3): 48–52.
8. Brincat M, Moniz CJ, Studd JW, Darby A, Magos A, Emburey G, et al. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynaecol. 1985;92:256–9. doi: 10.1111/j.1471-0528.1985.tb01091.
9. Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP, et al. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas. 1999;33:239–47. doi: 10.1016/S0378-5122(99)00077-8.
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